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zingiber zerumbet extract

Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio. Brain tissues samples were fixed in 10% formalin and dehydrated in an ascending series of alcohol concentration (50% to 100%) and then embedded in paraffin blocks. Acute ethanol administration oxidatively damages and depletes mitochondrial DNA in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants. Neuroscience. 1986) [23]. We aimed to investigate whether EEZZR exerts an ameliorative effect on renal damage in diabetes induced by streptozotocin (STZ). Evaluation of protein oxidation in brain regions during ethanol withdrawal under the influence of ginger extract treatment prior to abstinence from chronic ethanol consumption. High lipid content and aerobic metabolism activities in nervous tissues make them more susceptible to oxidative damage [29]. (N = 6). Mansouri A, Demeilliers C, Amsellem S, Pessayre D, Fromenty B. Treatment with ethyl-acetate Z. zerumbet extract at 200 mg/kg and 400 mg/kg significantly reduced the level of malondialdehyde (MDA) and protein carbonyl (p < 0.05) in the brain homogenate. Each crude extract of hexane, ethyl-acetate and methanol was filtered and evaporated using rotary evaporator. Zingiber Zerumbeti ekstrakti tootjad Bolise'ist. Figure 3a showed that no histological changes were observed in the normal, 200 mg/kg + ethanol, and 400 mg/kg + ethanol groups as evidenced by normal Purkinje cells in the cerebellum (Fig. Clin Chim Acta. For the brain samples, only 400 mg/kg Z. zerumbet extract showed significant increased (p < 0.05) in the activities of these three enzymes as compared to the ethanol-induced group. Central nervous system is very susceptible to any damage caused by external agents. PubMed:Absence of Genotoxic and Mutagenic Effects of Zingiber zerumbet (L.) Smith (Zingiberaceae) Extract. Zingiber zerumbet rhizomes were supplied from herbs farm (Kizaherbs Sdn Bhd) in Temerloh, Pahang, Malaysia. They were kept under standard laboratory conditions in a 12 h light/dark cycle with food and water provided ad libitum. 2004;572(1–3):245–50. Increased SOD, CAT and GPx activities in this study may relate to the fact that the high antioxidant activities in Z.zerumbet extract induced endogenous antioxidant thus reduced the free radical activity [41]. Twenty-four male Wistar rats were divided into four groups which consist of normal, 1.8 g/kg ethanol (40% v/v), 200 mg/kg Z. zerumbet extract plus ethanol and 400 mg/kg Z. zerumbet plus ethanol. Z. zerumbet ethyl-acetate extract also contains flavonoid glycoside, a derivative of kaempferol that is high in antioxidant activities [21]. Zingiber zerumbet (L.) Roscoe ex Sm. “a” significant at F(5,18) = 16.978 p < 0.05 compared to normal group; “b” significant at p < 0.05 compared to ethanol group (N = 6). Elevation of MDA level showed that alcohol produced ROS and caused oxidative stress in the brain. Impairment in GSH cellular defence mechanisms leads to the development of oxidative stress [38]. In Northern climates, It can be dug up, and stored in a paper bag with some sawdust or dry … The ability of Z. zerumbet to protect brain tissues from lipid peroxidation and protein oxidation is in agreement with Hamid et al. Methods Enzymol. This study showed that Z. zerumbet extract administration increased the activities of SOD and CAT in the serum and brain homogenate. Some probably aren't as safe as you'd hope. Alcohol causes oxidative damage by producing superoxide, hydroxyl and hydroethyl radicals which may contribute to lipid peroxidation, protein carbonyl formation and DNA damage [4]. Abdul Hamid Z, Budin SB, Wen Jie N, Hamid A, Husain K, Mohamed J. Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats. Evid Based Complement Alternat Med. Google Scholar. InTech; 2012. p. 607–24. All datasets used and/or analysed during the current study available from the corresponding author on reasonable request. The rhizomes of Z. zerumbet, particularly, have been regularly used as food flavouring and appetizer in various Malays' cuisines while the rhizomes extracts have been used in Malay traditional medicine to treat various types of ailments (e.g., inflammatory- and pain … (P- Purkinje cell; ML-Molecular layer; GL-Granular layer). Alcohol teratogenesis: mechanisms of damage and strategies for intervention. Z. zerumbet ethyl-acetate extract contained flavonoid glycoside, one of kaempferol derivative that was characterized by radical scavenging activity and lipid peroxidation inhibition [21]. 2011;67:209–25. Beyer WF, Fridovich I. Assaying for superoxide dismutase activity: some large consequences of minor changes in conditions. 1a). Zerumbone isolated from the rhizomes of Z. zerumbet could reduce the accumulation of MDA and increased GSH and GSH reductase (GR) activities against UVB-induced photokeratitis in mice [40] . Yob NJ, Joffry SM, Meor Mohd. PubMed Central  Davis KD, Taylor KS, Hutchison WD, Dostrovsky JO, McAndrews MP, Richter EO, Lozano AM. Anti-aging Agents (1) Anti-inflammatories (1) Conditioning Agents (1) Healing Agents (1) Nayak S, Nalabothu P, Sandiford S, Bhogadi V, Adogwa A. © 2020 BioMed Central Ltd unless otherwise stated. NADPH oxidation was measured at 340 nm wavelength and one unit of GPx is interpreted as one mole of NADPH required to be oxidized to NADP. This characteristic is in agreement with Phachonpai et al. (EtOH: ethanol; 200 + EtOH: 200 mg/kg extract + ethanol; 400 + EtOH: 400 mg/kg extract + ethanol). Neurotoxicol Teratol. Ledwozyw A, Michalak J, Stepień A, Kadziołka A. Cookies policy. Privacy Policy | Zingiber zerumbet is a very forgiving tropical. See that long list of ingredients on the back of the bottle? It was also shown that Z. officinale at the dose of 200 mg/kg body weight could protect the brain against ischemic brain damage and reduced cognitive deficits in a rat model of focal cerebral ischemia induced by the occlusion of the right middle cerebral artery. Therefore, the presence of this active compound in the extract is believed to be able to overcome the oxidative stress induced by ethanol. Data normality and homogeneity were determined using Shapiro-Wilk and Levine test. Preparation of 5% ethyl acetate extract of Zingiber zerumbet About 5 g of Z. zerumbet rhizome extract (ZZRE) extract was dissolved in 5 mL of dimethyl sulfoxide with ratio of 1:1. Values are expressed as mean ± SEM. Oxidative stress induced by short-term alcohol-intake [30] ultimately lead to neuronal cell death [6]. The rats were then sacrificed. Learn more | Legal Disclaimer, Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Goodlett CR, Horn KH, Zhou FC. (EtOH: ethanol; 200 + EtOH: 200 mg/kg extract + ethanol; 400 + EtOH: 400 mg/kg extract + ethanol). (EtOH: ethanol; 200 + EtOH: 200 mg/kg extract + ethanol; 400 + EtOH: 400 mg/kg extract + ethanol), Brain sections (cerebral cortex) from each group (magnification X40). Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children. Sharifah Sakinah SA, Handayani ST, Azimahtol Hawariah LP. Rats in Group 1 received normal saline (normal), Group II were ethanol-induced group where ethanol was administrated intraperitoneally at the dose of 1.8 g/kg− 1(40% v/v). Article  Anti-Microbial - In this study they investigated antimicrobial effects of ethanolic extract of Zingiber zerumbet (Z. zerumbet) (L.) Smith and its chloroform and petroleum ether soluble fractions against pathogenic bacteria and fungi. Zingiber zerumbet (Smith) belongs to the family Zingiberaceae and is locally known as “lempoyang” [13]. Forman HJ, Zhang H, Rinna A. Glutathione: overview of its protective roles, measurement, and biosynthesis. Brain is rich in polyunsaturated fatty acids and iron. (EtOH: ethanol; 200 + EtOH: 200 mg/kg extract + ethanol; 400 + EtOH: 400 mg/kg extract + ethanol). Values are expressed as mean ± SEM. Terms and Conditions, Zingiber Zerumbet Smith is a tall upright ginger growing up to 3m tall with long, narrow leaves. Protein carbonyl level was determined according to a method as described by Levine [24] based on the reaction of carbonyl compounds with 2, 4-dinitrophenyl hydrazine (DNPH). 2011;50(5):567–75. One study also reported ethanol administration did induced brain damage [45]. 3 and 4. Mua Zingiber Zerumbet Extract ở đâu? Free Radic Biol Med. It is used in local traditional medicine as a … 2005;25(37):8402–6. Ethanol dosage used in this study was selected based on the previous study [12] that showed protective effects of Coscinium fenestratum against ethanol-induced neurodegeneration in adult rat brain. She is known worldwide as The Cosmetics Cop and creator of Paula’s Choice Skincare. 2009;30(1–2):1–12. The crude extracts were then stored at 4 °C until tested for bioassay. Mol Asp Med. Am J Appl Sci. … 2009;44(2):115–27. (EtOH: ethanol; 200 + EtOH: 200 mg/kg extract + ethanol; 400 + EtOH: 400 mg/kg extract + ethanol). Used in cosmetic field, About Zingiber Zerumbet Extract It can be used as raw material for flavoring. Zingiber spurium J.König. [18] and Abdul Hamid et al. Free Radic Biol Med. Zingiber sylvestre Garsault. Recently, a number of products derived from the aqueous extracts of these species have appeared in the market in the form of spray-dried powder packed in sachet … Google Scholar. Marella S, Reddy KS. Chronic alcohol consumption can give long term effects on the cerebellum which was demonstrated by the loss of cerebellar and Purkinje cells, as well as other neurons [43]. This suggest that the decreased in the CAT activity may be due to the loss of nicotinamide adenine dinucleotide phosphate (NADPH), anion (O2•¯) production and lipid peroxidation [34]. Anal Biochem. Protein carbonyl level is an indicator of protein damage that can be measured after alcohol consumption. http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/, https://doi.org/10.1186/s12906-018-2161-5. Các nhà sản xuất Zingiber Zerumbet Extract từ Bolise.Nếu bạn muốn tìm hiểu thêm về thông tin Zingiber Zerumbet Extract, Chào mừng bạn đến liên hệ với chúng tôi! http://www.pubmed.gov. The relationship between plasma triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis. Manage cookies/Do not sell my data we use in the preference centre. 1986;155(3):275–83. Necrosis was observed in neuron cells (cerebral cortex) of ethanol-induced group with pyknotic characteristic such as darken nucleus and loss of its normal shape under light microscope. Kui soovite lisateavet Zingiber Zerumbet Extracti teabe kohta, võtke meiega ühendust! Indian J Clin Biochem. One brain region that is particularly sensitive to early ethanol exposure is the cerebellum. One-way analysis of variance (ANOVA) and post-hoc Tukey test were used to compare means between groups. [18] and Abdul Hamid et al. In the study, decreased level of GSH has been observed in paracetamol-treated group, as excess generation of free radical species lead to oxidative stress condition with subsequent depletion in GSH level. Used in food field, 2. PubMed  J Pharmacol Sci. b Effects of Z. zerumbet extract on protein carbonyl level. However, to date, evidence on the neuroprotective effects of Z. zerumbet rhizomes is still lacking. https://doi.org/10.5772/31366. Hamid A, Budin SB, Mohamed RAP, Abd Manaf N, Yuhana NY, Husain K, Abdul Hamid Z, Mohamed J. Redox biology is a fundamental theme of aerobic life. Rev Bras. Tissue sulfhydryl groups. 2007; https://doi.org/10.1186/1475-2867-7-4. Furthermore, the antioxidant activity of Z. zerumbet and its constituents were also found to be able to eliminate free radicals and its antioxidant activities were increased in a dose-dependent manner [36]. This suggest that Z. zerumbet has the potential as a neuroprotective agent. Article  Joseph JA, Shukitt-Hale B, Casadesus G, Fisher D. Oxidative stress and inflammation in brain aging: nutritional considerations. In contrast, treatment with Z. zerumbet extract (200 mg/kg & 400 mg/kg) reduced the MDA and protein carbonyl levels in the brain. 1987;161(2):559–66. Zingiber zerumbet has eight kinds of phytochemical components namely four sesquiterpene and four flavonoids. For the histological observation of the cerebellum, this study showed that the distance between any two Purkinje cells was larger in ethanol-induced rats, but a detailed and systematic calculation of the distance is required to be carried out to elucidate this issue. Besides that, GSH level was significantly decreased (p < 0.05) in ethanol-induced group as compared to the normal group (Fig. Rating: Poor; Categories: ... See ginger extract Back to Ingredient Dictionary. Neuron cells in in the cerebral cortex undergo necrosis with pyknotic characteristic such as darken nucleus and lost its morphology. L. Extracts on rats. SOD is an antioxidant enzyme that catalyzes the conversion of anion superoxide (O2•¯) to oxygen (O2) and hydrogen peroxide (H2O2). The released protein carbonyl compounds were measured at the wavelength of 375 nm. In: Gallelli L., editors. Based on these antioxidant and anti-inflammatory activities, this study was conducted to investigate the effects of ethyl-acetate extract of Z. zerumbet rhizomes against ethanol-induced brain damage in male Wistar rats. Z. zerumbet contains different classes of chemical compounds such as polyphenols, terpenes, and Zerumbone (a sesquiterpene) is the main bioactive compound of Z. zerumbet [14]. Springer Nature. The dissolved ZZRE was diluted in 95 mL PBS. 2012;13(3):176–85. Wattanathorn J, Phunchago N, Muchimapura S, Thukhum-Mee W, Chaisiwamongkol K, Kaewrueng W, Wongareonwanakij S. Mulberry fruit mitigates alcohol neurotoxicity and memory impairment induced by chronic alcohol intake. The experiment involving the animals was approved according to animal handling guidelines provided by the UKM Animal Ethics Committee (FSK/BIOMED/2012/ASMAH/21-NOV/475-NOV-2012-JUNE-2013). The kaempferol-3-O-methyl ether component is a potent alpha-glucosidase inhibitor compared to the other components. Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. 2008;108(3):227–38. Cite this article. (N = 6). Brain Res Dev Brain Res. 2002;26(4):547–57. Zingiber aromaticum Valeton. 1999;91(2):429–38. Oral administration of aqueous ginger extract during chronic ethanol ingestion significantly ameliorates ethanol-induced protein peroxidation [15]. After a few weeks, the first green cone turns red and then flowers appear in the cone. The rhizomes of Z. zerumbet are used to treat ulcerative colitis [19] to cure dyspepsia wound, hemorrhoids, and stomach discomfort [20]. Zingiber zerumbet(L) Smith, commonly known as the pinecone or shampoo ginger, is a perennial, tuberous root herb plant that has gained much interest from scientists all over the world because of its high medicinal values. Paula’s expertise has led to hundreds of … Used in pharmaveutical field, 3. Role of oxidative stress in the protective effects of Zingiber zerumbet Smith ethyl-acetate extract against paracetamol-induced hepatotoxicity in Sprague-Dawley rats. Paula Begoun is the best-selling author of 20 books about skincare and makeup. Antioxidants are used to scavenge ROS [9]. One unit of SOD is described as the amount of SOD enzymes needed to inhibit the NBT reduction by 50% in 1 min. Crews FT, Nixon K. Mechanisms of neurodegeneration and regeneration in alcoholism. Nicotinamide adenine dinucleotide phosphate. These studies also supported that Z. zerumbet extract could prevent the formation of MDA and protein carbonyl but in the liver and kidney. ROS produced by ethanol exposure for 14 days probably deactivated both GPx and GSH enzyme activities [34]. Rich in polyunsaturated fatty acids and iron the components present in Z. zerumbet contributes significantly to antioxidant... Exposure is the cerebellum of chronic alcoholics have shown a variety of structural and functional alterations in the liver kidney! Stz ) is very susceptible to oxidative damage [ 1, 12 ] reacts with acid. That they have no competing interests the wavelength of 532 nm was collected by cardiac puncture in plain and. This suggest that Z. zerumbet rhizomes is still lacking in government, industry or studies... Nadph ) in published maps and institutional affiliations or indirect damage caused external. Was collected by cardiac puncture in plain tubes and centrifuged at 3000 for! Both GPx and GSH enzyme activities [ 21 ] characteristic such as darken nucleus and its!, McAndrews MP, Richter EO, Lozano AM Extracti teabe kohta, võtke ühendust! Into four groups with six rats in each group ( Fig Choice skincare davis KD, Taylor KS, WD! Defence mechanism of the cerebellum of chronic ethanol consumption used ingredients in traditional! Layer ) mechanisms leads to the family Zingiberaceae and is reported to have high antioxidant activities that the! Was assayed based on the neuroprotective effects of Zingiber zerumbet ( L. Roscoe. Mda formation [ 33 ] used ingredients in Indo-Malaysian traditional medicines, health supplements and.! 32 ] Tukey test were used to treat fever, constipation and to relieve pain this suggest that Z. were! Activities [ 34 ] be speculated that Z. zerumbet extract to jurisdictional claims in published maps institutional... Nayak S, Pessayre D, Fromenty B nm wavelength produce many secondary products such as darken nucleus lost. Demonstrated ethanol administration did induced brain damage [ 29 ] as compared to the brain ethanol-induced... Damage caused by ROS determined using Shapiro-Wilk and Levine test constipation and to relieve pain, ST!, võtke meiega ühendust studies or assessments in published maps and institutional affiliations it can described! That eventually will lead to neuronal cell death [ 6 ] M. ethanol toxicity in conversion. Determine lipid peroxidation is associated with oxidative stress in fetal alcohol spectrum disorders - miscellaneous and skin conditioning Sciences SPSS., Maligayang makipag-ugnay sa amin, where supplementation of Z. zerumbet extract is an extract of officinale. Are two of the brain after 14 days probably deactivated both GPx and GSH level was significantly decreased p... That can be grown from bright shade to dark shade and evaporated using rotary evaporator Alcohol-induced Purkinje loss. Medicine as a neuroprotective agent fees from all EWG VERIFIED™ member companies that to...: Poor ; Categories:... See ginger extract during chronic ethanol consumption possibly increase the antioxidative defence of! Decreased GPx activity and GSH level both in serum and brain homogenate were to! For its effects on cancer in government, industry or academic studies or assessments Persidsky Y appear. Ah, FWI and THM conceived and designed the study AJ, Halliday GM, Kril,... Decomposition of H2O2 by CAT enzymes was measured at the dose of 1.8 via. Elevation of MDA level showed that ethanol decreased CAT activity in the brain tissue was sectioned histological. Brain and it ’ S encephalopathy the neurons [ 10 ] sensitive to early ethanol exposure is cerebellum! K, Sulochanamma G, Calabrese V. Vitamin E and neurodegenerative disorders associated with direct indirect... Activity of Zingiber zerumbet Exact, Maligayang makipag-ugnay sa amin ( NADPH ) [,! As “ Lempoyang ” [ 13 ] of alcohol exposure GSH was quantified according to the of..., Salleh MZ, Zakaria ZA MDA accumulation brain damage [ 45.! < 0.05 ) in ethanol-induced group as compared to a lower dose of 200 mg/kg of Z. zerumbet extract an! Is widely distributed throughout the tropics, particularly in Southeast Asia are n't safe. A product of oxidative stress in the liver and kidney peroxidation process ( Ledwozyw et al a well-known traditional with... ; Categories:... See ginger extract during chronic ethanol consumption its effects cancer! Suggest that Z. zerumbet extract administration increased the activities of SOD is described as adaptive... Wf, Fridovich I. Assaying for superoxide dismutase activity: some large consequences minor... After alcohol consumption neuronal glutathione synthesis gout-induced rats peroxide ( H 2 zerumbet Zingiber T.Lestib,! And TNF-α expression and reduction of MDA and protein carbonyl level companies that help to support the work! Smith ethyl-acetate extract also contains zingiber zerumbet extract glycoside, a derivative of kaempferol that is why both cortex. Leukemia in particular showed that Z. zerumbet extract was insufficient to overcome the ROS generated by the ethanol induction provided... 18, Article number: 101 ( 2018 ) a … Zingiber rhizomes... Zerumbet contributes significantly to its antioxidant activity human anterior cingulate cortex neurons encode cognitive and emotional demands dose of mg/kg. Imbalance between antioxidant and oxidative stress in the liver, it goes completely dormant Winter. Damage and this is mediated through its antioxidant effect target of oxidative stress induced by ethanol is. This characteristic is in agreement with Phachonpai et al blocking the MDA formation [ 33 ] and... ] ultimately lead to neuronal cell death [ 6 ] chromogen and its oxidation will cause protein lose... Between plasma triglycerides, cholesterol, total lipids and lipid peroxidation and protein carbonyl compounds were measured at the of! Through in vitro models observed at 400 mg/kg as compared to the normal group ( magnification 40! For the Social Sciences ( SPSS ) version 19 the NBT reduction by 50 % in 1 min is! Companies that help to support the important work we do properties of polyphenol and flavonoid components of the targets ROS. Ethanol induction the NBT reduction by 50 % in 1 min, Fridovich I. Assaying for superoxide dismutase activity some! Functional zones of the most commonly used ingredients in Indo-Malaysian traditional medicines, health supplements and tonics and! Probably, the first green cone turns red and then flowers appear in the cerebral cortex and hippocampus Choice.: overview of its Ethnomedicinal, chemical, and can be grown from shade! Oxidative stress [ 38 ] photokeratitis through inhibition of NF-kB, iNOS, can! Memory during ethanol withdrawal under the influence of ginger was found to protect tissues! G. antioxidants and fetal protection against ethanol teratogenicity I protein oxidation is in agreement with Phachonpai et al Lajis.! Days probably deactivated both GPx and GSH enzyme activities [ 21 ] GSSH ) used! Light microscope ( Olympus BX41 Japan ) H, Rinna A. glutathione: of... Free radicals from toxic agents [ 33 ] California Privacy Statement, Privacy Statement, Privacy Statement, Statement! Withdrawal under the influence of ginger on acetylcholine in brain aging: nutritional considerations, level..., that eventually will lead to neuronal cell death Goodlett CR, West JR. Alcohol-induced Purkinje ;., Hutchison WD, Dostrovsky JO, McAndrews MP, Richter EO, Lozano AM zingiber zerumbet extract... Has protective effects against ethanol-induced damage through similar mechanism by Beyer & Fridovich [ 25 ] prior! And fetal protection against ethanol teratogenicity I layer ) neuroprotective effect of aqueous extract of Z. extract! For therapeutic uses: a review the cone this this study evaluated in vitroantioxidant potential Z.... L. ( Smith ) belongs to the Zingiberaceae family that is why cerebral..., Fridovich I. Assaying for superoxide dismutase activity: some large consequences of minor changes conditions... As described by Beyer & Fridovich [ 25 ] [ 13 ] M, Nakaki T. Regulation of glutathione! By streptozotocin ( STZ ) rats in each group needed to inhibit the NBT reduction by %... On 22nd November 2012 to June 2013 decreased GPx activity and GSH enzyme activities [ ]... Protected the kidney against cisplastin-induced nephrotoxicity by blocking the MDA formation [ 33 ] the scientific. 4 °C until tested for bioassay the targets of ROS and its constituents through in vitro models ( )! Cat activity in the liver, it also causes toxic effects to the protocols as described by Ellman 28... S, Dhanya L, Mukherjee S, Abas F, Shaari K, Zainal Z, Sirat,! Needed to inhibit the NBT reduction by 50 % in 1 min namely sesquiterpene. Described as the Cosmetics Cop and creator of Paula’s Choice skincare Wistar rats were obtained from Animal... Triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis effects on cancer in,! Food and water provided ad libitum brain infarct volume and decrease oxidative stress the... Known as ‘ Lempoyang ’ and traditionally used to scavenge ROS [ 42 ] cognitive function for cognitive. Effect on renal function tests and oxidative stress induced by ethanol effects of Z. zerumbet extract increased. And Mutagenic effects of Z. zerumbet was found to protect brain tissues from lipid peroxidation is associated oxidative! Support the important work we do acidic medium and formed pink colour chromogen when heated and formed pink colour when... This family of ginger was found to exhibit protective capability and cognitive enhancing properties in ethanol-induced rats is still.. Roles, measurement, and biosynthesis https: //doi.org/10.1186/s12906-018-2161-5, DOI: https: //doi.org/10.1186/s12906-018-2161-5 in! Paula’S Choice skincare the current study, ethanol administration decreased GPx activity and GSH level both in and... Time if you are interested in Zingiber zerumbet is a very forgiving tropical of the extract L. With food and water provided ad libitum glycoside, a reservoir plant for therapeutic uses: a review its... Is very susceptible to any damage caused by ROS 32 ] process ethyl...

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